Use of simple amino acids to form porous particles during spray drying
AssigneeAdvanced Inhalation Research, Inc.
InventorsRichard P. Batycky, Michael M. Lipp, Ralph W. Niven
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Abstract
Particles having a tap density of less than 0.4 g/cm3 include a hydrophobic amino acid or salt thereof and a therapeutic, prophylactic or diagnostic agent or any combination thereof. Preferred particles include a phospholipid, have a median geometric diameter between about 5 and about 30 microns and an aerodynamic diameter between about 1 and about 5 microns. The particles can be formed by spray-drying and are useful for delivery to the pulmonary system.
Claims31
A method for drug delivery to the respiratory system comprising:
- administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of spray dried particles wherein said particles consist of a therapeutic, prophylactic or diagnostic agent, or any combination thereof, an amino acid or salt thereof, and a phospholipid or combination of phospholipids and wherein the particles have a tap density less than about 0.4 g/cm3.
Spray dried particles consisting of a therapeutic, prophylactic or diagnostic agent, or any combination thereof, an amino acid or salt thereof, and a phospholipid or combination of phospholipids;
- wherein the particles have a tap density less than about 0.4 g/cm3.
Dependencies are inferred from the claim text.