Solid preparation
AssigneeTakeda Chemical Industries, Ltd.
InventorsToshihiro Shimizu, Masae Sugaya
Life of this patent
Estimating the term…
Abstract
A solid preparation which comprises (i) a pharmaceutically active ingredient, (ii) one or more water-soluble sugar alcohol selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, and (iii) low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight; which exhibits excellent buccal disintegration and dissolution and also appropriate strength.
Claims19
A solid preparation comprising:
- (i) lansoprazole or voglibose,
- (ii) one or more water-soluble sugar alcohols selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, and
- (iii) low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight;
- wherein said low-substituted hydroxypropylcellulose is incorporated in an amount of 3 to 50 weight parts per 100 weight parts of the solid preparation;
- wherein said solid preparation is capable of buccal disintegration or dissolution.
A method for use of low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight for the manufacture of a pharmaceutical preparation capable of buccal disintegration or dissolution comprising
- blending a pharmaceutically active ingredient, one or more water-soluble sugar alcohols and a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- molding said preparation;
- and
- optionally drying said preparation.
A method of improving buccal disintegration or dissolution of a solid pharmaceutical preparation comprising adding a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to a solid pharmaceutical preparation.
A method for preparing a solid preparation comprising
- blending a pharmaceutically active ingredient, one or more water-soluble sugar alcohols selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol and a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- molding said preparation and then
- optionally drying said preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A method for improving buccal disintegration of a solid pharmaceutical preparation comprising
- blending a pharmaceutically active ingredient, one or more water-soluble sugar alcohols selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol with a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A method for preparing a solid preparation comprising
- blending
- a pharmaceutically active ingredient,
- one or more water-soluble sugar alcohols selected from the group consisting of maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, and
- a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- molding said preparation and then
- optionally drying said preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A method for improving buccal disintegration of a solid pharmaceutical preparation comprising
- blending
- a pharmaceutically active ingredient and
- one or more water-soluble sugar alcohols selected from the group consisting of maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, with
- a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A solid preparation comprising:
- (i) lansoprazole or voglibose,
- (ii) erythritol, and
- (iii) low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight, wherein said low-substituted hydroxypropylcellulose is incorporated in an amount of 3 to 50 weight parts per 100 weight parts of the solid preparation,
- wherein said preparation is capable of buccal disintegration or dissolution.
A method for preparing a solid preparation comprising
- blending
- a pharmaceutically active ingredient,
- erythritol and
- a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- molding said preparation and then
- optionally drying said preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A method for improving buccal disintegration of a solid pharmaceutical preparation comprising
- blending
- a pharmaceutically active ingredient and
- erythritol with
- a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A method for preparing a solid preparation comprising
- blending
- a pharmaceutically active ingredient,
- one or more water-soluble sugar alcohols selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, and
- a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation
- wherein said low-substituted hydroxypropylcellulose is incorporated in an amount of 5 to 40 weight parts per 100 weight parts of the solid preparation;
- molding said preparation and then
- optionally drying said preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
A method for improving buccal disintegration of a solid pharmaceutical preparation comprising
- blending
- a pharmaceutically active ingredient,
- one or more water-soluble sugar alcohols selected from the group consisting of sorbitol, maltitol, reduced starch saccharide, xylitol, reduced palatinose and erythritol, with
- a low-substituted hydroxypropylcellulose having hydroxypropoxyl group contents of 7.0 to 9.9 percent by weight to form a solid preparation
- wherein said low-substituted hydroxypropylcellulose is incorporated in an amount of 5 to 40 weight parts per 100 weight parts of the solid preparation;
- wherein said solid preparation is bucally dissolved in from about 5 to about 50 seconds.
Dependencies are inferred from the claim text.