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US 6,585,976 B1Granted
Mycobacterium strain with modified ERP gene and vaccine composition containing same
AssigneeInstitut Pasteur
InventorsBrigitte Gicquel, François-Xavier Berthet
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Abstract
The invention concerns Mycobacterium strains whereof the erp gene is modified and a vaccine composition containing same. The modification of the erp gene decreases the virulence and the persistence of the Mycobacterium strains.
Claims13
A Mycobacterium strain with a modified erp gene in its genome, wherein the Mycobacterium strain is selected from Mycobacterium tuberculosis species and Mycobacterium bovis species, and wherein said strain is incapable of expressing the product of the active erp gene.
Dependencies are inferred from the claim text.