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US 6,585,975 B1Granted
Use of Salmonella vectors for vaccination against helicobacter infection
AssigneeAcambis Inc.
InventorsHarold Kleanthous, Patricia Londono-Arcila, Donna Freeman, Cynthia K. Lee, Thomas P. Monath
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Abstract
The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
Claims15
A method of inducing an immune response against Helicobacter in a mammal, said method comprising the steps of:
- mucosally administering to said mammal an attenuated Salmonella vector comprising a nucleic acid molecule encoding a Helicobacter antigen, and
- parenterally administering to said mammal a Helicobacter antigen.
Dependencies are inferred from the claim text.