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US 6,585,973 B1Granted
Method for preparing solid phase conjugated vaccine
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorAndrew Lees
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Abstract
A method of preparing conjugate vaccines by adsorbing a protein to a solid phase adjuvant, and covalently linking a carbohydrate to the adsorbed protein. Alternatively, the carbohydrate is first adsorbed to the solid phase adjuvant, then the protein is covalently linked to the carbohydrate. The carbohydrate may be chemically activated. Unconjugated protein may be present.
Claims10
A method for preparing a solid phase vaccine, comprising the steps of:
- (a) adsorbing a protein to a solid phase adjuvant;
- and
- (b) covalently linking a carbohydrate to the adsorbed protein,
- wherein both the protein and the carbohydrate are capable of inducing an immune response, and wherein step (a) is performed before step (b).
1 more element
Dependencies are inferred from the claim text.