Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina

A process for removing the vitreous from the eye of a patient comprising the steps of:

• introducing a composition into the vitreous of the eye of a patient in need thereof in an amount effective to present or inhibit retinal hemorrhaging, retinal tears and retinal detachment, said composition comprising a collagen crosslinking agent, plasminogen, a plasminogen activator, and a pharmaceutically acceptable carrier, said composition being introduced into said vitreous in an amount to induce crosslinking of collagen in said vitreous and to induce separation of posterior hyaloid from the inner limiting membrane in said eye, wherein each of said components of said composition are introduced into the eye in a non-toxic amount substantially without inflammation;
• and
• removing the vitreous from said eye.

A process for inducing posterior vitreous detachment in the eye of a patient in need thereof to prevent or inhibit retinal tears and retinal detachment, comprising the step of:

• introducing a composition into the vitreous of the eye of a patient in need thereof in an amount effective to present or inhibit retinal hemorrhaging, retinal tears and retinal detachment, said composition comprising a pharmaceutically acceptable carrier, a collagen crosslinking agent, recombinant plasminogen and recombinant urokinase, said composition being introduced into said vitreous in an amount to induce crosslinking of collagen in said vitreous and to induce separation of posterior hyaloid from the inner limiting membrane in said eye, wherein each of said components of said composition are introduced into the eye in a non-toxic amount substantially without inflammation.