Intraocular lenses and process for the producing molded-in type intraocular lenses

A process for the production of a one-piece intraocular lens having an optic portion which functions as a substitute lens for a crystalline lens and a haptic portion for fixing and holding the optic portion in a predetermined position in an eye, the optic portion having an optical axis, wherein the haptic portion has a first angle with a plane at right angles with the optical axis of the optic portion and through an optical center of the lens as the haptic portion extends outwardly from its start portion in the vicinity of the optic portion, and the haptic portion has a first bendable portion which is bent so as to form a second angle, an angle opposite to the first angle, with said plane in a position located outside the start portion of the haptic portion and a second bendable portion which is bent so as to form a third angle, an angle opposite to the second angle, with said plane in a position located outside the first bendable portion, wherein at least the first and second bendable portions of the haptic portion from a proximal end to a distal end extend radially farther away from the optical center of the lens,

• the process comprising polymerizing an optic-portion-forming monomer mixture containing:
• (a) 5 to 20% by weight of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate of the formula (I),
• wherein R1 hydrogen or methyl,
• (b) 40 to 70% by weight of 2-phenylethyl (meth)acrylate of the formula (II),
• wherein R2 is hydrogen or methyl,
• (c) 25 to 50% by weight of alkyl (meth)acrylate of the formula (III)
• wherein R3 is hydrogen or methyl and R4 is a C4-C12 linear, branched or cyclic alkyl group, and
• (d) 0.5 to 5% by weight, based on the total amount of the components (a) to (c), of a crosslinking monomer, while keeping the monomer mixture in contact with a haptic-portion-forming material containing polymethyl methacrylate, or polymerizing a haptic-portion-forming monomer containing methyl methacrylate while keeping the haptic-portion-forming monomer in contact with an optic-portion-forming material formed of a copolymer obtained by polymerization of the above monomer mixture, to integrate the optic-portion-forming material and the haptic-portion-forming material, and thereafter cutting and polishing the integrated product.

A soft intraocular lens having an optic portion formed of a deformable soft material which functions as a substitute lens for a crystalline lens and a haptic portion which is formed of arm members extending outwardly from circumferential portions of the optic portion and is for fixing and holding the optic portion in a predetermined position in an eye, the optic portion having an optical axis,

• wherein the haptic portion has a first angle with a plane at right angles with the optical axis of the optic portion and through an optical center of the lens as the haptic portion extends outwardly from its start portion in the vicinity of the optic portion, and the haptic portion has a first bendable portion which is bent so as to form a second angle, an angle opposite to the first angle, with said plane in a position located outside the start portion of the haptic portion and a second bendable portion which is bent so as to form a third angle, an angle opposite to the second angle, with said plane in a position located outside the first bendable portion, wherein at least the first and the second bendable portions of the haptic portion from a proximal end to a distal end extend radially farther away from the optical center of the lens, and when a compressive force is externally exerted on the haptic portion so as to move at least any site of the haptic portion toward the optic portion, the haptic portion can absorb at least part of the external compressive force by deformation which decreases the force to be transmitted to the optic portion.

A soft intraocular lens having an optic portion formed of a deformable soft material which functions as a substitute lens for a crystalline lens and a haptic portion which is formed of arm members extending outwardly from circumferential portions of the optic portion and is for fixing and holding the optic portion in a predetermined position in an eye, the optic portion having an optical axis,

• wherein the haptic portion has a first angle with a plane which passes a start portion of the haptic portion and which is in the direction at right angles with the optical axis of the optic portion, the haptic portion extending outwardly from the start portion in the vicinity of the optic portion, and the haptic portion has a first bendable portion which is bent so as to form a second angle, an angle opposite to the first angle, with said plane in a position located outside the start portion of the haptic portion and a second bendable portion which is bent so as to form a third angle, an angle opposite to the second angle, with said plane in a position located outside the first bendable portion, the haptic portion thus crossing an imaginary line parallel to said plane and extending through an optical center of the lens, wherein each bendable portion of the haptic portion extends away from the optical center of the lens, and when a compressive force is externally exerted on the haptic portion so as to move at least any site of the haptic portion toward the optic portion, the haptic portion can absorb at least part of the external compressive force by deformation which decreases the force to be transmitted to the optic portion.

A process for the production of a one-piece intraocular lens having an optic portion which functions as a substitute lens for a crystalline lens and a haptic portion for fixing and holding the optic portion in a predetermined position in an eye, the optic portion having an optical axis, the process comprising polymerizing an optic-portion-forming monomer mixture containing:

• (a) 5 to 20% by weight of 2-[2-(perfluorooctyl)ethoxy]-1-methylethyl (meth)acrylate of the formula (I),
• wherein R1 hydrogen or methyl,
• (b) 40 to 70% by weight of 2-phenylethyl (meth)acrylate of the formula (II),
• wherein R2 is hydrogen or methyl,
• (c) 25 to 50% by weight of alkyl (meth)acrylate of the formula (III)
• wherein R3 is hydrogen or methyl and R4 is a C4-C12 linear, branched or cyclic alkyl group, and
• (d) 0.5 to 5% by weight, based on the total amount of the components (a) to (c), of a crosslinking monomer, while keeping the monomer mixture in contact with a haptic-portion-forming material containing polymethyl methacrylate, or polymerizing a haptic-portion-forming monomer containing methyl methacrylate while keeping the haptic-portion-forming monomer in contact with an optic-portion-forming material formed of a copolymer obtained by polymerization of the above monomer mixture, to integrate the optic-portion-forming material and the haptic-portion-forming material, and thereafter cutting and polishing the integrated product
• wherein the haptic portion has a first angle with a plane which passes a start portion of the haptic portion and which is in the direction at right angles with the optical axis of the optic portion, the haptic portion extending outwardly from the start portion in the vicinity of the optic portion, and the haptic portion has a first bendable portion which is bent so as to form a second angle, an angle opposite to the first angle, with said plane in a position located outside the start portion of the haptic portion and a second bendable portion which is bent so as to form a third angle, an angle opposite to the second angle, with said plane in a position located outside the first bendable portion, the haptic portion thus crossing an imaginary line parallel to said plane and extending through an optical center of the lens, wherein each bendable portion of the haptic portion extends away from the optical center of the lens, and when a compressive force is externally exerted on the haptic portion so as to move at least any site of the haptic portion toward the optic portion, the haptic portion can absorb at least part of the external compressive force by deformation which decreases the force to be transmitted to the optic portion.

A soft intraocular lens having an optic portion formed of a deformable soft material which functions as a substitute lens for a crystalline lens and a haptic portion which is formed of arm members extending outwardly from circumferential portions of the optic portion and is for fixing and holding the optic portion in a predetermined position in an eye, the optic portion having an optical axis,

• wherein the haptic portion has a first angle with a plane which passes a start portion of the haptic portion and which is in the direction at right angles with the optical axis of the optic portion, the haptic portion extending outwardly from the start portion in the vicinity of the optic portion, and the haptic portion has a first bendable portion which is bent so as to form a second angle, an angle opposite to the first angle, with said plane in a position located outside the start portion of the haptic portion and a second bendable portion which is bent so as to form a third angle, an angle opposite to the second angle, with said plane in a position located outside the first bendable portion, the haptic portion thus crossing an imaginary line parallel to said plane and extending through an optical center of the lens, wherein each bendable portion of the haptic portion extends away from the optical center of the lens, and wherein that portion of each haptic portion which is positioned outside the second bendable portion is formed so as to be nearly in parallel with a plane at right angles with the optical axis, and when a compressive force is externally exerted on the haptic portion so as to move at least any site of the haptic portion toward the optic portion, the haptic portion can absorb at least part of the external compressive force by deformation which decreases the force to be transmitted to the optic portion.