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OwnerAlexei I. Trushin, Alexandr V. Vinogradov +1inventors
InventorsAlexei I. Trushin, Alexandr V. Vinogradov, Mikhail L. Stakhanov
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Non-invasive, contract-free method for the diagnostics of the proliferation areas of biological tissue and their localization zones n vivo in a live organism on the basis of visualizing the fluorescence of endogenous porphyrins and a device for implementing this method. Tissue is irradiated with low intensity monochrome radiation in the wave length band of 630 to 645 nm and the fluorescent image is recorded within the band of 650 to 730 nm. Recording is carried out in one or several cycles, the brightness values of the corresponding points in the images are averaged for all recording cycles, the significant brightness range of the averaged image is established and broadened by way of re-calculation with regard to the entire dynamic range of the display device. A color reference image of the tissue and auxiliary images are recorded additionally at the excitation wave length and at the fluorescence wave length with illumination from the corresponding sources, and the fluorescent images of the natural proliferation areas of the same patient and a fluorescing test object are recorded. The device for implementing this method contains an additional laboratory premises lighting source.
Proliferation area diagnostics method the essence of which is in radiating tissue surface under examination with the radiation inducing the internal fluorescence of endogenous porphyrins and their complexes with proteins and recording the fluorescence of endogenous porphyrins and their complexes with proteins the distinctive feature of which is that the tissue segment under examination is irradiated with an even monochrome radiation beam in the wave length band of 630 to 645 nm, the fluorescent image of the tissue segment under examination is recorded only in the spectral wave band of 650 to 730 nm, and proliferation intensity change areas are determined by formal signs in the fluorescent image.
A device for proliferation area diagnostics which comprises a monochrome source of the radiation inducing the fluorescence of endogenous porphyrins and their complexes with proteins, a fluorescent image recording unit, a reference image recording unit, a computer with graphical information display, output, documenting and storage devices the distinctive feature of which is that the monochrome source of radiation inducing the fluorescence of endogenous porphyrins and their complexes with proteins radiates in the wave length band of 630 to 645 nm, the fluorescent image recording unit is made in the form of a monochrome CCD-camera with variable frame exposure time and comprises additionally a white light source for illuminating the tissue surface under examination when recording colour reference image, a unit for switching radiation sources and making a collinear configuration of rays, a unit for collinear illumination of the tissue under examination and receiving reflected signals and the fluorescent signal, an image splitting unit, a radiation filtration unit, a video, synchronisation and control signal processor linked to a computer, the fluorescent image recording unit, the reference image recording unit, the unit for switching radiation from sources and making a collinear ray configuration, the radiation filtration unit and the radiation sources.
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