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US 6,583,321 B1Granted
4′-methanesulfonyl-biphenyl derivatives as a highly selective cyclooxygenase-2 inhibitor
AssigneeCheil Jedang Corporation
InventorsIl Hwan Cho, Jee Woong Lim, Ji Young Noh, Jong Hoon Kim, Sang Wook Park, Hyung Chul Ryu, Je Hak Kim, Hyung Ok Chun, So Young Wang, Eun Young Lee
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Abstract
The present invention relates to a novel 4′-methanesulfonyl-biphenyl derivative having a structure of formula 1 and its pharmaceutically acceptable salts as a highly selective cyclooxygenase-2 inhibitor. <Formula 1> Wherein, R1 and R2 are defined in this specification respectively.
Claims3
A compound of formula 1 and its pharmaceutically acceptable salts:
- Wherein, R1 and R2are respectively a hydrogen;
- C1-C4-alkyl substituted or not substituted by halogens;
- C3-C7-cycloalkyl;
- C1-C5-alkyl containing 1˜3 ether bonds and/or an aryl substitute;
- substituted or not substituted phenyl;
- or substituted or not substituted five or six ring-cycled heteroaryl containing more than one hetero atoms selected from a group consisting of nitrogen, sulfur and oxygen (wherein, phenyl or heteroaryl can be one- or multi-substituted by a substituent selected from a group consisting of hydrogen, methyl, ethyl and isopropyl).
3 more elements
Dependencies are inferred from the claim text.