Method for synthesis of α-sulfonamido amide, carboxylic acid and hydroxamic acid derivatives
AssigneeAdvanced Syntech, LLC
InventorsEugene Campian, Boliang Lou, Adnan M. M. Mjalli
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Abstract
A method of synthesizing α-sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three reactants to form an array of polymer-bound α-sulfonamido amide-type intermediates and use of such intermediates for the preparation of combinatorial libraries.
Claims6
A method for synthesizing α-sulfonamido amide, α-sulfonamido carboxylic acid and α-sulfonamido hydroxamic acid derivatives comprising carrying out a four component condensation reaction between components consisting of a sulfonamide, an aldehyde or ketone, an isocyanide and a carboxylic acid, one of said components being attached to a solid support.
Dependencies are inferred from the claim text.