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US 6,583,297 B2Granted
Process and intermediate compounds for the preparation of pyrrolidines
AssigneeBoard of Trustees operating Michigan State University
InventorRawle I. Hollingsworth
Life of this patent
Estimating the term…
Abstract
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.
Claims4
A process for the preparation of a pyrrolidone lactam of the formula:
- which comprises reducing an oxime or imine of the formula:
- with a source of singlet hydrogen (H) or hydride to form the pyrrolidone lactam, wherein R is selected from the group consisting of acyloxy, acetoxy, alkyloxy, hydroxyl, alkyl, aryl and hydrogen, R1 to R3 are hydrogen or a protecting group and Me is methyl.
Dependencies are inferred from the claim text.