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US 6,583,280 B1Granted
Polyamine analogues having antiproliferative activity
OwnerNada H. Saab-Ishmailinventor
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Abstract
Novel compounds are chiral compounds which are conformationally restricted polyamine analogues for use in imaging and for therapeutic use in treatment of tumors. These analogues diminish the ability to aggregate DNA seen in the parent polyamines. The invention provides for synthesis of a library of analogues with fine structural modifications which retain restriction and conservation of the molecular weight of the parent polyamines.
Claims3
A compound which is of the formula:
- wherein R1 and R2 are each chosen from among H and alkyl of 1-6 carbons and n is 1-3.
A compound which is of the formula:
- wherein R1 and R2 are each chosen from among H or alkyl of 1-6 carbons and n may be 1-3.
A compound of the formula:
- wherein R1 and R2 are each chosen from among H or alkyl of 1-6 carbons and n may be 1-3.
Dependencies are inferred from the claim text.