Semaphorin K1
AssigneeExelixis, Inc.
InventorsYuling Luo, Xiaomei Xu
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Abstract
The invention provides methods and compositions relating to semaphorin K1 (sema K1) polypeptides which regulate cellular guidance and physiology, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed sema K1 encoding nucleic acids or purified from human cells. The invention provides isolated sema K1 hybridization probes and primers capable of specifically hybridizing with the disclosed sema K1 genes, sema K1-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Claims16
An isolated or recombinant polynucleotide encoding a polypeptide comprising a sequence selected from the group consisting of:
- (a) at least 100 contiguous residues of SEQ ID NO:2.
- (b) at least 60 contiguous residues of residues 340-634 of SEQ ID NO:2, and
- (c) at least 12 contiguous residues of residues 481-634 of SEQ ID NO:2,
- wherein the polypeptide has a functionality selected from the group consisting of enhancing organotypic neurite outgrowth from damaged neurons undergoing nerve fiber atrophy and eliciting a SemaK1-specific antibody.
An isolated or recombinant polynucleotide comprising SEQ ID NO:1, or a fragment thereof encoding a polypeptide comprising a sequence selected from the group consisting of:
- (a) at least 100 contiguous residues of SEQ ID NO:2,
- (b) at least 60 contiguous residues of residues 340-634 of SEQ ID NO:2, and
- (c) at least 12 contiguous residues of residues 481-634 of SEQ ID NO:2,
- wherein the polypeptide has a functionality selected from the group consisting of enhancing organotypic neurite outgrowth from damaged neurons undergoing nerve fiber atrophy and eliciting a SemaK1-specific antibody.
Dependencies are inferred from the claim text.