Hydrogel-forming system with hydrophobic and hydrophilic components
AssigneeCornell Research Foundation, Inc.
InventorsChee-Youb Won, Yeli Zhang, Chih-Chang Chu
Life of this patent
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Abstract
A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.
Claims4
A hydrogel forming system which comprises hydrophobic and hydrophilic components (A) and (B) which are convertible into a one phase crosslinked network structure by free radical polymerization, where the hydrophobic and hydrophilic components constitute different compounds from one another, the hydrophobic component (A) being a hydrophobic macromer with unsaturated group terminated ends, and the hydrophilic component (B) being a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, the unsaturated group introducing compound being selected from the group consisting of acryloyl chloride, methacryloyl chloride, acrylic acid, methacrylic acid and isocyanate having unsaturated group at one end of the molecule, the hydrogel-forming system comprising from 0.01 to 99.00% by weight of (A) and from 99.99 to 0.01% of (B), with the total of the percentages of (A) and (B) being 100%.
Dependencies are inferred from the claim text.