N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
AssigneeNeurogen Corporation
InventorsRaymond F. Horvath, Ping Ge, Taeyoung Yoon, Alan Hutchison
Life of this patent
Estimating the term…
Loading patent…
AssigneeNeurogen Corporation
InventorsRaymond F. Horvath, Ping Ge, Taeyoung Yoon, Alan Hutchison
Estimating the term…
Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein; A is N or CH; R1 and R2 represents hydrogen or lower alkyl; G, R3, R4, R5, R6, R7 and R8 are variables defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorders, anxiety, depression, eating disorders, and stress disorders in humans and other animals. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
A compound of the formula:
A compound of the formula:
Dependencies are inferred from the claim text.