Methods and kits for treating and diagnosing leiomyomas
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsStephen S. Palmer, Romana A. Nowak
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Abstract
This invention provides methods of treating a subject suffering from a leiomyoma which comprise administering to the subject a therapeutically effective amount of an agent, or alternatively a plurality of agents, which inhibit specific metalloproteinases. This invention further provides diagnostic methods of determining whether a tumor in a subject is a leiomyoma. This invention further provides pharmaceutical compositions and kits for practicing the instant methods. Finally, this invention provides a method of determining whether an agent specifically inhibits certain metalloproteinases.
Claims18
A method of treating a subject suffering from a leiomyoma which comprises inhibiting at least one metallopreinase selected from the group consisting of stromelysin-2, stromelysin-3 and matrilysin.
A pharmaceutical composition for treating a subject suffering from a leiomyoma which comprises an agent which specifically inhibits at least one metalloproteinase selected from the group consisting of stromelysin-2, stromelysin-3 and matrilysin, and a pharmaceutically acceptable carrier wherein the composition comprises an imadazole hydroxyamate of the formula:
- wherein R2, X and Y are CH2CHMe2, H and Ph, respectively, and R1 is CH2CHMe2 or C—C6H11.
Dependencies are inferred from the claim text.