Agent for inhibition of cytokine production and agent for inhibition of cell adhesion

A method for inhibiting production of TNF-α, IL-1β, IL-6 and IFN-γ by administering to a patient in need thereof an agent for inhibiting production of TNF-α, IL-1β, IL-6 and IFN-γ comprising, as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula:

• wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the phenyl ring;
• and
• R2 is a group represented by the formula:
• wherein m is an integer of 1-3 and the R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by —(A)l—NR4R5 (wherein A is a lower alkylene group;
• R4 and R5,
• which may be the same or different, are each a hydrogen atom or a lower alkyl group;
• and
• l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.

A method for inhibiting TNF-α production by administering to a patient in need thereof an agent for inhibiting TNF-α production comprising, as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula:

• wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the phenyl ring;
• and
• R2 is a group represented by the formula:
• wherein m is an integer of 1-3 and the R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by —(A)l—NR4R5 (wherein A is a lower alkylene group;
• R4 and R5, which may be the same or different, are each a hydrogen atom or a lower alkyl group;
• and
• l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.

A method for treating ARDS by administering to a patient in need thereof an agent for treating ARDS, comprising, as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula:

• wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the phenyl ring;
• and R2 is a group represented by the formula:
• wherein m is an integer of 1-3 and the R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by —(A)l—NR4R5 (wherein A is a lower alkylene group;
• R4 and R5, which may be the same or different, are each a hydrogen atom or a lower alkyl group;
• and
• l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.

A method of treating asthma by administering to a patient in need thereof an agent for treating asthma comprising, as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula:

• wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the phenyl ring;
• and
• R2 is a group represented by the formula:
• wherein m is an integer of 1-3 and the R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by —(A)l—NR4R5 (wherein A is a lower alkylene group;
• R4 and R5, which may be the same or different, are each a hydrogen atom or a lower alkyl group;
• and
• l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.

A method of treating Crohn disease by administering to a patient in need thereof an agent for treating Crohn disease, comprising as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula:

• wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the phenyl ring;
• and
• R2 is a group represented by the formula:
• wherein m is an integer of 1-3 and R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by —(A)l—NR4R5 (wherein A is a lower alkylene group;
• R4 and R5, which may be the same or different, are each a hydrogen atom or a lower alkyl group;
• and
• l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.

A method for treating uveitis by administering to a patient in need thereof an agent for treating uveitis comprising, as the active ingredient, a thiazole compound or a pharmaceutically acceptable salt thereof of the formula:

• wherein R1 is a phenyl group which may have one or more lower alkoxy groups as a substituent on the pheny ring;
• and
• R2 is a group represented by the formula:
• wherein m is an integer of 1-3 and the R3s, which may be the same or different, are each a carboxyl group, a lower alkoxy group, a lower alkyl group, a lower alkenyl group, a group represented by —(A)l—NR4R5 (wherein A is a lower alkylene group;
• R4 and R5, which may be the same or different, are each a hydrogen atom or a lower alkyl group;
• and
• l is 0 or 1), a hydroxyl group-substituted lower alkyl group, a lower alkoxy group-substituted lower alkoxy group, a lower alkoxy group-substituted lower alkoxycarbonyl group or a carboxyl group-substituted lower alkoxy group.