2-pyridinylguanidine urokinase inhibitors

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, or solvate of either entity,
• wherein
• R1 is H, halogen, CN, C1-6 alkyl optionally substituted by one or more halogen, or C1-6 alkoxy optionally substituted by one to three halogens,
• R2 and R3 are each independently H, halogen, C1-6 alkyl optionally substituted by one or more halogen or C1-6 alkoxy, (Cn-alkylene)CO2H, (Cn-alkylene)CO2(C1-6 alkyl), (Cn-alkylene)CONR5R6, CH═CHR7, CH═CHCO2H, CH═CHCONR5R6, CH═CHSO2NR5R6, C═CR7, O(Cm-alkylene)OH, O(Cm-alkylene)OR8, OR8, O(Cm-alkylene)CONR5R6, CH2OR8 or CH2NR5R6,
• R4 is N═C(NH2)2 or NHC(═NH)NH2,
• R5 and R6 are each independently H, C1-6 alkyl optionally substituted by OH or CO2H
• R7 is C1-6 alkyl;
• R8 is C1-6 alkyl;
• n is 0, 1 or 2;
• m is 1 or 2;
• and wherein the “C-alkylene” linking groups in the definitions above are optionally substituted by one or more C1-6 alkyl;
• with the proviso that R1, R2 and R3 are not all H.