US 6,583,160 B2 · Nicotine therapy method and oral carrier for assuaging tobacco-addiction

Abstract

A method for assuaging tobacco addiction comprises pulsing doses of nicotine into a user's bloodstream so it reaches the brain before passing through the liver. A nicotine-burst tablet is held in the mouth by a user to receive each nicotine-pulse dose. The tablet is configured to suddenly release its entire nicotine payload from an otherwise inert or benign material. Such nicotine payload is relatively small, e.g., under one milligram. The therapeutic effects depend on the change of nicotine levels in the blood over a change in time. Rapid nicotine onset of a small dose is more assuaging than a slow build-up to a high dosage. An oral carrier comprises a nicotine saturated instant-dissolve paper that delivers one nicotine pulse. An additive prevents abuse by causing excessive use to catalyze a foul taste or sickening sensation.

Claims4

Dependent claims

An oral tablet, comprising:

a paper disk of absorbent and saliva-dissolvable material;
and
a nicotine base in liquid form deposited on and absorbed by the paper disk;
wherein, the nicotine base further includes citric acid and water, and the combined mixture weighs about 9.5 milligrams before being allowed to dry on the paper disk, wherein about 1.8 milligrams is nicotine available for absorption in said mouth of a user;
wherein, such combination provides for the delivery of a sharp, intense burst of the nicotine base when exposed to saliva in a mouth of said user.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

09/938,375Filed 23 Aug 2001 · continuation in part

Priority

14 Apr 1999

Published

US 2002/0002189 A13 Jan 2002

Granted

24 Jun 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 9/0056
Mouth and digestive tract, i.e. intraoral and peroral administration: mouth soluble or dispersible forms; Suckable, eatable, chewable coherent…
A61K 9/006
Mouth and digestive tract, i.e. intraoral and peroral administration: oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or…
A61K 9/2086
Characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets;…: layered…
A61K 9/209
Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat: containing drug in at least two layers or in the core and in at…

Family

Application09/292,045Parent of this continuation-in-part · filed 14 Apr 1999

Application09/771,454Parent of this continuation-in-part · filed 29 Jan 2001

US 6,248,760 B1Parent of this continuation-in-part · filed 19 Jun 2001

US 2002/0002189 A1Pre-grant publication · published 3 Jan 2002

US 2001/0016593 A1Published application

US 6,583,160 B2This patent

From the US filing history. Foreign family members aren’t listed.

Nicotine therapy method and oral carrier for assuaging tobacco-addiction

Life of this patent

Nicotine therapy method and oral carrier for assuaging tobacco-addiction

Life of this patent

Abstract

Claims4