Pharmaceutical composition based on polyaromatic compounds
AssigneeLaboratorie L. Lafon
InventorsEvelyne Delfourne, Nathalie Bontemps-Subielos, Francis Darro, Jean Bastide, Robert Kiss, Armand Frydman
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Abstract
A pharmaceutical composition comprising an efficient amount of a compound selected among the compounds of formulae (I) and (II). The compounds have useful cytotoxic properties providing therapeutic application as antitumoral medicine.
Claims9
A pharmaceutical composition comprising an effective amount of a compound chosen from the compounds of formulae:
- in which:
- R1, R3, R4, R5 and R6 are chosen from hydrogen, halogens and hydroxyl, —CHO, —OR, —COOH, —CN, —CO2R, —CONHR, —CONRR′,
- —NH2, —NHR, —N(R)2, —NH—CH2—CH2—N(CH3)2, —NHCOR, morpholino, nitro and —SO3H groups,
- R and R′ being chosen from C1-C6 alkyl groups and Ar being a C6-C14 aryl group,
- R2 is chosen from nitro and —NHCOCF3 groups,
- with the exclusion of the compounds of formula I in which R1=—OH or —NH2 and R3, R4, R5 and R6 =H,
- and the addition salts of these compounds with pharmaceutically acceptable acids,
- in admixture with a pharmaceutically acceptable excipient.
A compound which is selected from the group consisting of:
- 4-(2-trifluoroacetamidophenyl)pyrido[3,2-g]quinoline-5,10-dione,
- 6-methoxy-4-(2-trifluoroacetamidophenyl)pyrido-[3,2-g]quinoline-5,10-dione,
- 6-(dimethylamino)-4-(2-trifluoroacetamidophenyl)-pyrido[3,2-g]quinoline-5,10-dione,
- 6-(acetamido)-4-(2-trifluoroacetamidophenyl)pyrido-[3,2-g]quinoline-5,10-dione,
- 8-methoxy-4-(2-trifluoroacetamidophenyl)pyrido-[3,2-g]quinoline-5,10-dione,
- ethyl 4-(2-trifluoroacetamidophenyl)-5,10-dioxo-pyrido[3,2-g]quinoline-7-carboxylate,
- 8-methoxy-4-(2-nitrophenyl)pyrido[3,2-g]quinoline-5,10-dione,
- ethyl 4-(2-nitrophenyl)-5,10-dioxopyrido[3,2-g]-quinoline-7-carboxylate,
- benzo[b]pyrido[4,3,2-de][1,7]phenanthroline-8-one,
- 12-dimethylaminobenzo[b]pyrido[4,3,2-de][1,7]-phenanthroline-8-one,
- 10-hydroxybenzo[b]pyrido[4,3,2-de][1,7]phenanthroline-8-one,
- 10-methoxybenzo[b]pyrido[4,3,2-de][1,7]phenanthroline-8-one,
- 11-ethylbenzo[b]pyrido[4,3-de][1,7]phenanthrolinecarboxylate-8-one,
- and the salts thereof with pharmaceutically acceptable acids.
A method for treating a patient with a solid tumor, comprising the administration to this patient of an effective amount of a compound chosen from the compounds of formulae:
- in which:
- R1, R3, R4, R5 and R6 are chosen from hydrogen, halogens and hydroxyl, —CHO, —OR, —COOH, —CN, —CO2R, —CONHR, —CONRR′,
- —NH2, —NHR, —N(R)2, —NH—CH2—CH2—N(CH3)2, —NHCOR, morpholino, nitro and —SO3H groups,
- R and R′ being chosen from C1-C6 alkyl groups and Ar being a C6-C14 aryl group,
- R2 is chosen from nitro and —NHCOCF3 groups,
- with the exclusion of the compounds of formula I in which R1=—OH or —NH2 and R3, R4, R5 and R6=H,
- and the addition salts of these compounds with pharmaceutically acceptable acids.
Dependencies are inferred from the claim text.