Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same

A compound represented by formula (I) and pharmaceutically acceptable salt and solvate thereof:

• wherein
• A represents
• group —CR1R2—(CH2)i— wherein R1 and R2, which may be the same or different, represent a hydrogen atom or alkyl having 1 to 6 carbon atoms and i is an integer of 0,
• —CH═CH—,
• —O—CH2—, or
• —S(O)j—CH2— wherein j is an integer of 0 to 2;
• B represents a hydrogen or halogen atom,
• X represents
• —CR3R4R5 wherein R3, R4, and R5, which may be the same or different, each represent a hydrogen atom or phenyl, provided that any one of R3, R4, and R5 represents phenyl and one or more hydrogen atoms on phenyl may be substituted by a halogen atom, hydroxyl, nitro, phenyl, or alkoxy having 1 to 6 carbon atoms,
• —NR6R7 wherein R6 and R7, which may be the same or different, each represent a hydrogen atom, phenyl, or benzyl,
• —(CH2—CH═C(CH3)—CH2)p—CH2CH═C(CH3)2 wherein p is an integer of 0 to 2,
• alkyl having 1 to 18 carbon atoms,
• cycloalkyl having 3 to 8 carbon atoms,
• phenyl optionally substituted by hydroxy, a halogen atom, nitro, alkoxy having 1 to 6 carbon atoms, or phenyl,
• cinnamyl optionally substituted by hydroxy, a halogen atom, nitro, phenyl, or alkoxy having 1 to 6 carbon atoms, or
• a five- or six-membered heteroaromatic ring containing up to two hetero atoms;
• Y represents —(CH2)q— wherein q is an integer of 1 to 6,
• —CH═CH—,
• —NR8 wherein R8 represents a hydrogen atom or alkyl having 1 to 6 carbon atoms,
• an oxygen atom, or
• a bond;
• Z represents carbonyl or a bond;
• K represents alkylene having 1 to 6 carbon atoms optionally substituted by hydroxy, a halogen atom, alkyl having 1 to 6 carbon atoms, or alkoxy having 1 to 6 carbon atoms, or represents a bond;
• L represents —CH═CH— or a bond;
• and
• M represents a hydrogen atom,
• alkyl having 1 to 6 carbon atoms optionally substituted by hydroxy, a halogen atom, amino, alkoxy having 1 to 6 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms,
• cycloalkyl having 3 to 8 carbon atoms optionally substituted by hydroxy, a halogen atom, amino, alkoxy having 1 to 6 carbon atoms, alkylcarbonyloxy having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms,
• phenyl optionally substituted by alkyl having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, a halogen atom, amino, alkoxy having 1 to 4 carbon atoms, alkylcarbonyl having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms,
• a five- or six-membered, saturated or unsaturated heterocyclic ring containing up to two hetero atoms optionally substituted by alkyl having 1 to 4 carbon atoms,
• biphenyl optionally substituted by alkyl having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, a halogen atom, amino, alkoxy having 1 to 4 carbon atoms, alkylcarbonyl having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms, or
• diphenylmethyl optionally substituted by alkyl having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, a halogen atom, amino, alkoxy having 1 to 4 carbon atoms, alkylcarbonyl having 1 to 4 carbon atoms, or alkoxycarbonyl having 1 to 4 carbon atoms.