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US 6,583,127 B1Granted
Use of etherlysophospholipids as antiinflammatory agents
AssigneeInkeysa. SA
InventorsConsuelo Gajate, Jose Camprubi
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Abstract
The present invention relates to the use of a series of etherlysophospholipids (ELPs) for the preparation of a medicament for the treatment of an inflammatory disease without causing adverse gastrointestinal side effects and/or without inhibition of phospholipase A2 and prostaglandin E2, as well as preventing or treating ulcerative conditions of the gastrointestinal tract.
Claims23
A method for the prevention or treatment of an inflammatory disease comprising administering an effective amount of formula (I):
- wherein R1 is a C12-C18 straight or branched alkyl group;
- R2 is C1-C8 straight or branched alkyl group;
- and R3 is:
- or the salts, enantiomers and diastereomers thereof, to a patient in need thereof.
1 more element
A method for the prevention or treatment of chronic inflammatory diseases associated with
- (a) ulcerative conditions of the gastrointestinal tract,
- (b) inflammatory bowel diseases,
- (c) inflammatory diseases of the respiratory airways,
- (d) inflammatory processes derived from alcoholic liver, or
- (e) another inflammatory disease selected from the group consisting of pemphigus vulgaris, polymyositis-dermatomyositis, Sjögren-syndrome, Lyme disease, lupus erythematosus and Behcet's disease
- comprising administering an effective amount of formula (I):
- wherein R1 is a C12-C18 straight or branched alkyl group;
- R2 is C1-C8 straight or branched alkyl group;
- and R3 is:
- or the salts, enantiomers and diastereomers thereof, to a patient in need thereof.
7 more elements
Dependencies are inferred from the claim text.