Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)

A compound represented by formula I:

• or a pharmaceutically acceptable salt or prodrug thereof, wherein:
• R1 is phenyl or C1-6 alkyl, wherein said R1 is optionally substituted with 1-7 substituents independently selected from —C(O)OH, SC1-3alkyl, CN, halogen, —C(O)OC1-6alkyl(Rc)0-3, —C(O)NRaRb, OC1-6alkyl(Rc)0-3, C1-6alkyl(Rc)0-3, C(O)C1-6alkyl(Rc)0-3, —NHC(O)C1-4alkyl(Rc)0-3, NHC(O)NHC1-4alkyl(Rc)0-3, and —NHC(O)NH—Ar, wherein Ar is phenyl, wherein said Ar is optionally substituted with 1-3 substituents independently selected from halogen, C1-3alkyl, C1-3fluoroalkyl, OC1-3alkyl, and OC1-3fluoroalkyl;
• Ra and Rb are each independently selected from the group consisting of H and C1-4alkyl;
• Each Rc is independently selected from a group consisting of OH, OC1-3alkyl, OC1-3haloalkyl, C0-6alkylene CO2H, Aryl, and Aryl substituted with 1-3 substituents independently selected from halogen, C1-4alkyl, C1-4haloalkyl, OC1-4alkyl, and OC1-4haloalkyl;
• R2 is phenyl, R2 being optionally substituted with 1-3 halogens;
• Z1 is a bond;
• Z2 is —C(O)—, S, SO, SO2, CH2, or a bond;
• Y1 and Y2 are each a bond or an aliphatic linear or branched hydrocarbon group having from 1-8 carbon atoms and 0-4 double bonds, and an optional cycloalkyl group having 3-6 carbon atoms as part of said hydrocarbon group;
• each W1 is independently selected from H and halogen;
• W2 is selected from the group consisting of H, —OCF2CO2H, —CF2PO3H2, —C(O)OC1-6alkyl, and Ar, wherein Ar is optionally substituted with 1-3 substituents independently selected from halogen, C1-3alkyl, C1-3fluoroalkyl, OC1-3alkyl, and —OC1-3fluoroalkyl;
• with the proviso that when all W1 groups are H, R1 is phenyl, R2 is phenyl and Y1 and Y2 are CH2, then one or both of R1 and R2 are substituted, and R1, if substituted, is substituted with a substituent other than fluorine or —SCH3.