Aromatic amides, preparation method and application as medicines

A compound selected from the group consisting of a compound of the formula

• wherein Y is selected from the group consiting of oxygen, ═N-Nalk, and ═Noalk2, alk1 and alk2 are individually alkyl of 1 to 12 carbon atoms optionally interrupted by at least one member of the group consisting of oxygen, sulfur and nitrogen and optionally substituted with at least one member of the group consisting of halogen, aryl, haloaryl, heterocyclic and
• Ra and Rb are individually hydrogen or substituted or unsubstituted alkyl of 1 to 8 carbon atoms or Ra and Rb with the nitrogen to which they are attached form a heterocycle which may contain another hetero atom selected from the group consisting of oxygen, sulfur and nitrogen, X is selected from the group consisting of hydrogen, —OH, linear, branched or cyclic alkyl, alkenyl and alkynyl of up to 12 carbon atom's optionally interrupted by at least one member of the group consisting of oxygen, nitrogen and sulfur, optionally substituted by at least one member of the group consisting of halogen, heterocycle, —OH, acyloxy, —CN, —NO2,
• wherein Ra and Rb are defined as above, alkoxy of up to 12 carbon atoms,
• wherein Rc and Rd have the definition of Ra and Rb, Re is alkyl of 1 to 8 carbon atoms unsubstituted or substituted as above, Z is selected from the group consisting of hydrogen, halogen and —OH free or esterified or etherified, R2 is hydrogen or halogen, R3 is selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, R is hydrogen or alkyl of 1 to 4 carbon atoms, R1 is selected from the group consisting of hydrogen, —CN, aryl of 6 to 14 carbon atoms and alkyl, cycloalkyl, alkenyl and alkynyl of up to 8 carbon atoms unsubstituted or substituted with at least one halogen, R5 is hydrogen or alkoxy of 1 to 4 carbon atoms, R6 is alkenyl of 2 to 3 carbon atoms and R7 is hydrogen or alkyl of 1 to 8 carbon atoms and its non-toxic, pharmaceutically acceptable acid addition salts.