Fracture healing using pthrp analogs
AssigneeRoche Palo Alto LLC
InventorBrian Henry Vickery
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Abstract
This invention provides methods of bone healing and fracture repair comprising administering to a patient in need thereof an effective amount of a polypeptide analog of parathyroid hormone related peptide (PTHrP) and salts thereof, wherein amino acid residues 22-31 form an amphipathic α-helix. Systemic administration is a preferred mode of delivery.
Claims28
A method of bone fracture repair comprising administering to a patient in need thereof a therapeutically effective amount of a polypeptide analog of parathyroid hormone related peptide (PTHrP) and salts thereof, in which amino acid residues 22-31 of said PTHrP analog form an amphipathic I-helix, for a time and under conditions to achieve said fracture repair.
A method of treatment for non-union bone fracture repair comprising administering to a patient in need thereof a therapeutically effective amount of a polypeptide analog of PTHrP and salts thereof, in which amino acid residues 22-31 of said PTHrP analog form an amphipathic I-helix, for a time and under conditions to achieve said fracture repair.
Dependencies are inferred from the claim text.