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US 6,583,112 B1Granted
Gene products related to werner's syndrome
OwnerYing-Hui Fu, Chang-En Yu +3inventors
InventorsYing-Hui Fu, Chang-En Yu, Junko Oshima, John T. Mulligan, Gerard D. Schellenberg
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Abstract
The present invention discloses nucleic acid molecules encoding WRN gene products, expression vectors and host cells suitable for expressing such products.
Claims4
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) SEQ ID NO:71;
- b) a polypeptide encoded by a nucleic acid molecule comprising SEQ ID NO:70;
- c) a polypeptide encoded by a nucleic acid molecule that binds to a nucleic acid molecule of (b) in 5×SSPE, 0.5% SDS at 65° C., or equivalent conditions, wherein said polypeptide is a Werner syndrome (WRN) gene product;
- and
- d) a polypeptide encoded by a nucleic acid molecule that is derived from the coding region of (b), wherein said polypeptide is a Werner syndrome (WRN) gene product.
2 more elements
A composition comprising
- (i) an isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) SEQ ID NO:71;
- b) a polypeptide encoded by a nucleic acid molecule comprising SEQ ID NO:70;
- c) a polypeptide encoded by a nucleic acid molecule that binds to a nucleic acid molecule of (b) in 5×SSPE, 0.5% SDS at 65° C., or equivalent conditions, wherein said polypeptide is a Werner syndrome (WRN) gene product;
- and
- d) a polypeptide encoded by a nucleic acid molecule that is derived from the coding region of (b), wherein said polypeptide is a Werner syndrome (WRN) gene product, and
- (ii) a physiologically acceptable carrier or diluent.
4 more elements
An isolated polypeptide comprising an amino acid sequence as set forth in SEQ ID NO:71.
An isolated polypeptide encoded by a polynucleotide comprising SEQ ID NO:70.
Dependencies are inferred from the claim text.