Use of agents which bind G proteins for treating septic shock
OwnerRobert W. Finberg, Evelyn A. Kurt-Jones +1inventors
InventorsRobert W. Finberg, Evelyn A. Kurt-Jones, Keith R. Solomon
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Abstract
The present invention provides for the use of G protein binding agents for prophylactic and/or therapeutic treatment of septic shock. The present invention provides methods of using agents which bind G protein to treat a subject having or susceptible to septic shock. The present invention further pertains to compositions for treating a subject for septic shock. The composition includes an effective amount of a G protein binding agent such as mastoparan and, optionally, an antibiotic and a pharmaceutically acceptable carrier. Other aspects of the invention include packaged agents which bind G proteins for treating septic shock.
Claims6
A method for treating septic shock in a subject, wherein the septic shock is endotoxic shock induced by gram positive bacteria, comprising administering to the subject an effective amount of an agent which binds G protein, to thereby inhibit the interaction of said G protein and CD14, such that septic shock in the subject is treated.
Dependencies are inferred from the claim text.