Therapeutic polypeptides from β-hCG and derivatives
OwnerRobert C. Gallo, Joseph Bryant +1inventors
InventorsRobert C. Gallo, Joseph Bryant, Yanto Lunardi-Iskandar
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Abstract
The present invention relates to peptides of one or more portions of the human chorionic gonadotropin β-chain peptides containing a sequence of one or more portions of the β-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or preparations of human chorionic gonadotropin, such as fractions of human early pregnancy urine, which fractions have anti-HIV activity, anti-cancer activity, and/or pro-hematopoietic activity. The present invention further relates to pharmaceutical compositions for treating and/or preventing HIV infection, cancer, and/or for promoting hematopoiesis.
Claims102
An isolated protein or peptide:
- (a) comprising at least one amino acid segment selected from the group consisting of:
- (i) a 5 to 50 amino acid segment of the sequence of β-hCG (SEQ ID NO:2);
- and
- (ii) a derivative of the segment of (a) having one or more conservative substitutions relative to the sequence of β-hCG (SEQ ID NO:2);
- (b) exhibiting at least one therapeutic effect selected from the group consisting of:
- (i) reduction of HIV viral load or prevention of progression of HIV infection in a subject infected with HIV;
- (ii) reduction of cancer cells or prevention of progression of cancer in a subject with cancer;
- and
- (iii) promotion of hematopoiesis resulting in an increased hematopoietic cell count or slowed progression of a degenerative hematopoeitic deficiency in a subject in need thereof;
- with the proviso that the protein or peptide does not comprise the full-length native sequence of β-hCG (SEQ ID NO:
- 2) and with the proviso that the protein or peptide does not consist of β-hCG 109-119 (segment of SEQ ID NO:
- 2) or 109-145 (segment of SEQ ID NO:
- 2).
A peptide consisting of the amino acid sequence of β-hCG 41-54 (SEQ ID NO:
- 3).
A peptide consisting of the amino acid sequence of β-hCG 45-54 (SEQ ID NO:
- 4).
A peptide consisting of the amino acid sequence of β-hCG 47-53 (SEQ ID NO:
- 5).
A peptide consisting of the amino acid sequence of β-hCG 45-57 (SEQ ID NO:
- 6).
A peptide consisting of the amino acid sequence of β-hCG 41-53 (SEQ ID NO:
- 8).
A peptide consisting of the amino acid sequence of β-hCG 42-53 (SEQ ID NO:
- 9).
A peptide consisting of the amino acid sequence of β-hCG 43-53 (SEQ ID NO:
- 10).
A peptide consisting of the amino acid sequence of β-hCG 44-53 (SEQ ID NO:
- 11).
A peptide consisting of the amino acid sequence of β-hCG 44-57 (SEQ ID NO:
- 12).
A peptide consisting of the amino acid sequence of β-hCG 45-53 (SEQ ID NO:
- 13).
A peptide consisting of the amino acid sequence of β-hCG 46-53 (SEQ ID NO:
- 14).
A peptide consisting of the amino acid sequence of β-hCG 45-55 (SEQ ID NO:
- 16).
A peptide consisting of the amino acid sequence of β-hCG 45-56 (SEQ ID NO:
- 17).
A peptide consisting of the amino acid sequence of β-hCG 45-58 (SEQ ID NO:
- 18).
A peptide consisting of the amino acid sequence of β-hCG 47-54 (SEQ ID NO:
- 19).
A peptide consisting of the amino acid sequence of β-hCG 47-57 (SEQ ID NO:
- 20).
A peptide consisting of the amino acid sequence of β-hCG 47-56 (SEQ ID NO:
- 21).
A peptide consisting of the amino acid sequence of β-hCG 47-58 (SEQ ID NO:
- 22).
A peptide consisting of the amino acid sequence of β-hCG 48-145 (SEQ ID NO:
- 23).
A peptide consisting of the amino acid sequence of β-hCG 58-145 (SEQ ID NO:
- 24).
A peptide consisting of the amino acid sequence of β-hCG 7-40 (SEQ ID NO:
- 33).
A peptide consisting of the amino acid sequence of β-hCG 46-65 (SEQ ID NO:
- 34).
A peptide consisting of the amino acid sequence of β-hCG 48-56 (SEQ ID NO:
- 35).
A peptide consisting of the amino acid sequence of β-hCG 41-54 (SEQ ID NO:
- 36).
Dependencies are inferred from the claim text.