Paramagnetic and active analogue (EMP-2) of melanocyte stimulating hormone containing amino acid-type stable free radical
AssigneeConselho Nacional de Desenvolvimento Cientifico e Technologico PROJUR/CNPq/AC
InventorsClóvis Ryuichi Nakaie, Eduardo Maffud Cilli, Maria Tereza Lamy-Freund, Simone dos Reis Barbosa
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Abstract
The present invention relates to an α-melanocyte stimulating hormone (α-MSH) analogue, labeled with an amino acid-type paramagnetic spin probe, for example, Toac, or 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, and methods for the synthesis thereof. The preferred analogue of the invention, acetyl-Toac0-α-MSH (abbreviated as EPM-2) is the first such analogue that maintains entirely the natural α-MSH activity.
Claims10
Acetyl-(2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid)-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-CONH2 (SEQ ID NO:1).
A method of synthesizing a paramagnetic and biologically active analogue of α-melanocyte stimulating hormone, comprising
- introducing a paramagnetic group internally into α-melanocyte stimulating hormone peptide sequence by means of an acylating agent.
Dependencies are inferred from the claim text.