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US 6,582,955 B2Granted
Bioreactor with application as blood therapy device
AssigneeSpectrum Laboratories, Inc.
InventorsF. Jesus Martinez, Virginia Thanh Ta
Life of this patent
Estimating the term…
Abstract
A bioreactor having an outer shell compartment containing many coaxial pairs of hollow microporous fibers. An annular compartment exists between an outer surface of the inner hollow microporous fiver and the inner surface of the outer hollow microporous fiber. The annular compartment preferably contains blood or plasma. The blood or plasma is, thus, exposed to two microporous hollow fibers which have fluids which can purify or otherwise affect the blood through the walls of two different microporous hollow fibers. An artificial liver or kidney can result when liver or kidney cells are placed in the shell compartment.
Claims13
A bioreactor comprising a three component module comprising:
- an outer shell having an inner surface defining the outer wall of an outer shell compartment, said outer shell compartment having an entry port and an exit port;
- at least one hundred outside fibers positioned within said outer shell compartment, said outside fibers having an outer surface exposed to said outer shell compartment and defining a cell containing compartment between said inner surface of said outer shell and said outer surface of said at least one hundred outside fibers and said at least one hundred outside fibers, each having an inner wall surrounding an outside fiber lumen and defining an outer wall of an annular compartment, said annular compartment sealed from said outer shell compartment and connected to an annular compartment manifold set having an annular compartment inlet port and an annular compartment outlet port;
- at least one inner fiber positioned within said outside fiber lumen and said at least one inner fiber having an outer wall surface defining an inner wall of said annular compartment and said at least one inner fiber having an inner wall surrounding an inner fiber lumen forming an inner compartment, said inner compartment sealed from said annular compartment and said outer shell compartment and said inner compartment being connected to an inner compartment manifold set having an inner compartment inlet port and an inner compartment outlet port;
- and
- wherein said outer shell compartment contains cells in a liquid medium, said annular compartment contains a circulating plasma containing perfusate and said inner compartment contains a different nutrient medium whereby a bioartificial organ can be operating carrying out two different functions.
2 more elements
A bioartificial liver comprising a three component module comprising:
- an outer shell having an inner surface defining the outer wall of an outer shell compartment, said outer shell compartment having an entry port and an exit port and said outer shell compartment containing liver cells;
- at least 100 outside fibers positioned within said outer shell compartment, said outside fibers having an outer surface exposed to said outer shell compartment and defining a cell containing compartment between said inner surface of said outer shell and said outer surface of said at least one hundred outside fibers and said at least one hundred outside fibers, each having an inner wall surrounding an outside fiber lumen and defining an outer wall of an annular compartment, said annular compartment sealed from said outer shell compartment and connected to an annular compartment manifold set having annular compartment inlet port and an annular compartment outlet port and said annular compartment is perfused with whole blood or plasma;
- and
- an inner fiber positioned within each of said at least one hundred outside fibers lumen and said inner fiber having an outer wall surface defining an inner wall of said annular compartment and said inner fiber having an inner wall surrounding an inner fiber lumen forming an inner compartment, said inner compartment sealed from said annular compartment and said outer shell compartment and said inner compartment being connected to an inner compartment manifold set having an inner compartment inlet port and an inner compartment outlet port and said inner compartment being used for blood purification therapy by means of either dialysis or ultrafiltration or diafiltration.
1 more element
A bioartificial kidney comprising a three component module comprising:
- an outer shell having an inner surface defining the outer wall of an outer shell compartment, said outer shell compartment having an entry port and an exit port, said outer shell compartment containing renal cells;
- a plurality of outside fibers positioned within said outer shell compartment, said plurality of outside fibers having an outer surface exposed to said outer shell compartment and defining a cell containing compartment between said inner surface of said outer shell and said outer surface of said plurality of outside fibers and said plurality of outside fibers having an inner wall surrounding an outside fiber lumen and defining an outer wall of an annular compartment, said annular compartment sealed from said outer shell compartment and connected to an annular compartment manifold set having an annular compartment inlet port and an annular compartment outlet port and said annular compartment is perfused with whole blood or plasma;
- and
- an inner fiber positioned within each of said plurality of outside fiber lumen and said inner fiber having an outer wall surface defining an inner wall of said annular compartment and said inner fiber having an inner wall surrounding an inner fiber lumen forming an inner compartment, said inner compartment sealed from said annular compartment and said outer shell compartment and said inner compartment being connected to an inner compartment manifold set having an inner compartment inlet port and an inner compartment outlet port and said inner compartment being used for blood purification by means of dialysis or ultrafiltration or diafiltration.
1 more element
Dependencies are inferred from the claim text.