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US 6,582,917 B1Granted
Method for controlling quality in the construction of oligomer grids
AssigneeDeutsches Krebsforschungszentrum
InventorMarkus Beier
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Abstract
The present invention relates to a method for controlling the quality of oligomer arrays, which is characterized in that a phosphate unit is fused to certain array positions, said phosphate unit being linked to a signal-generating reporter group, the degree of oligomer synthesis is determined using the signal of the reporter group, and the reporter group is then split off again.
Claims6
A method for controlling the quality of an oligonucleotide array, comprising the steps of:
- fusing a phosphate unit linked to a signal-generating reporter group to oligonucleotides bound at selected or all grid positions of an oligonucleotide array,
- determining the degree of oligomer synthesis by means of the signal of the reporter group attached to the oligonucleotides at the grid positions,
- preparing a quality control profile of the grid positions, and
- splitting off the reporter group.
1 more element
Dependencies are inferred from the claim text.