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US 6,582,916 B1Granted
Metal ion-binding mass markers for nucleic acids
AssigneeAventis Research & Technologies GmbH & Co. KG
InventorsGunter Schmidt, Andrew Hugin Thompson, Robert Alexander W. Johnstone
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Abstract
Provided is a method for characterising an analyte, which method comprises: a) providing a compound in which the analyte is attached by at cleavable linker to a mass marker relatable to the analyte; b) cleaving the mass marker from the analyte; and c) identifying the mass marker, thereby characterising the analyte, wherein the mass marker comprises a metal ion-binding moiety.
Claims39
A compound having the following formulas:
- N—L—M
- wherein N comprises an analyte, L comprises a cleavable linker between N and M, and M comprises a mass marker having a metal ion binding moiety.
A method for characterising an analyte that comprises:
- (a) providing a compound in which the analyte (N) is attached by a cleavable linker (L) to a mass marker (M) relatable to the analyte;
- (b) cleaving the mass marker from the analyte;
- and
- (c) identifying the mass marker, thereby characterising the analyte wherein the mass marker comprises a metal ion-binding moiety.
1 more element
Dependencies are inferred from the claim text.