Candida albicans KRE9 and uses thereof
AssigneeMcGill University
InventorsHoward Bussey, Marc Lussier, Anne-Marie Sdicu, Sarkis Serge Shahinian
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Abstract
The present invention to an isolated DNA which codes for a gene essential for cell wall glucan synthesis of Candida albicans, wherein the gene is referred to as CaKRE9, wherein the sequence of the DNA is as set forth in FIG. 1. The present invention relates to antifungal in vitro and in vivo screening assays for identifying compounds which inhabit the synthesis, assembly and/or regulation of β1,6-glucan. There is also disclosed an in vitro method for the diagnosis of disease caused by fungal infection in a patient.
Claims13
An isolated nucleic acid molecule, comprising the nucleotide sequence as set forth in SEQ. ID. NO:
- 1, encoding a gene product essential for cell wall glucan synthesis of Candida albicans.
An isolated nucleic acid molecule, comprising the nucleotide sequence encoding, amino acid sequence set forth in SEQ ID NO 2.
Dependencies are inferred from the claim text.