US 6,582,729 B1Granted

Powered pharmaceutical formulations having improved dispersibility

AssigneeNaktar Therapeutics

InventorsMohammad Eljamal, John S. Patton, Linda C. Foster, Robert M. Platz

Life of this patent

Estimating the term…

Abstract

Dispersibility of a respirable powder, administrable by inhalation, is increased by including a pharmaceutically acceptable water-soluble polypeptide.

Claims26

Dependent claims

A method for improving the dispersibility of a powder composition for inhalation by a human subject, said method comprising:

(a) providing a mixture comprising an active agent, a pharmaceutically acceptable excipient, and a dispersibility enhancing amount of a physiologically-acceptable, water-soluble polypeptide in water;
and
(b) spray drying the mixture provided in (a) to form a powder composition suitable for administration by inhalation,
wherein the composition is characterized by a delivered dose of greater than about 50%.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 09/638,510Filed 15 Aug 2000 · continuation
Priority: 14 Apr 1995
Granted: 24 Jun 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 9/0075
Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy: for inhalation via a dry…
A61K 9/1277
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: preparation processes;…
A61K 9/1617
Excipients; Inactive ingredients: organic compounds, e.g. phospholipids, fats
A61K 9/1623
Organic compounds, e.g. phospholipids, fats: sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Family

Application08/423,568Parent of this continuation-in-part · filed 14 Apr 1995
PCT/US96/05265Parent of this continuation · filed 15 Apr 1996
Application08/945,872Parent of this continuation
US 6,136,346 AParent of this continuation
Application08/945,872Parent of this continuation-in-part
US 6,582,729 B1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

Dispersibility of a respirable powder, administrable by inhalation, is increased by including a pharmaceutically acceptable water-soluble polypeptide.

Facts

Application

09/638,510Filed 15 Aug 2000 · continuation

Priority

14 Apr 1995

Granted

24 Jun 2003

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

A61K 9/0075
Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy: for inhalation via a dry…
A61K 9/1277
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: preparation processes;…
A61K 9/1617
Excipients; Inactive ingredients: organic compounds, e.g. phospholipids, fats
A61K 9/1623
Organic compounds, e.g. phospholipids, fats: sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Family

Application08/423,568Parent of this continuation-in-part · filed 14 Apr 1995

PCT/US96/05265Parent of this continuation · filed 15 Apr 1996

Application08/945,872Parent of this continuation

US 6,136,346 AParent of this continuation

Application08/945,872Parent of this continuation-in-part

US 6,582,729 B1This patent

From the US filing history. Foreign family members aren’t listed.