Cross linked solid supports for solid phase synthesis
AssigneeSmithKline Beecham Corporation
InventorsH. Mario Geysen, Patrick F. Kiser
Life of this patent
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Abstract
A method for performing chemical synthesis includes the steps of providing a solid support having cross links, a first set of cleavable links within the cross links, and a second set of cleavable links having sites on which to perform chemistry. A first chemical is coupled to the chemistry sites, and the first chemical is reacted with a second chemical to produce a reaction product. The links are cleaved to remove the cross links and to cleave the reaction product from the solid support.
Claims24
A method for performing chemical synthesis, the method comprising:
- providing a solid support having a plurality of cross links, a first set of cleavable links within the cross links, and a second set of cleavable links that provide sites on which to carry out chemistry;
- coupling a first chemical to the chemistry sites;
- reacting the first chemical with a second chemical to produce a reaction product;
- and
- cleaving the first links to remove the cross links and to permit the solid itself to separate and cleaving the second links to cleave the reaction product from the solid support.
A method for performing chemical synthesis, the method comprising:
- providing a series of polymer chains that are cross linked by cross links having a first set of cleavable links;
- attaching a second set of cleavable links to the polymer chains that provide sites on which to carry out chemistry;
- performing chemistry on the sites to produce one or more reaction products;
- and
- cleaving the first set of links to unlink the polymer chains and to permit the polymer chains themselves to separate and cleaving the second set of links to cleave the reaction products from the chemistry sites.
A method for performing chemical synthesis, the method comprising:
- providing a plurality of solid supports that each comprise a series of polymer chains that are cross linked with cross links having a first set of cleavable links and a second set of cleavable links that provide sites on which to carry out chemistry;
- performing chemistry on the sites to produce one or more reaction products;
- and
- cleaving the first and second set of links to unlink the polymer chains and to cleave the reaction products from the chemistry sites.
A solid support for performing chemical synthesis, comprising:
- a series of polymer chains cross linked by cross links;
- and
- a first set of cleavable links within the cross links;
- and
- a second set of cleavable links that provide sites on which to carry out chemistry.
A method for constructing a solid support, the method comprising:
- combining a set of components in a mixture, the components including a base set of monomers, a set of functional monomers for post polymerization modification, and a set of bivalent cross linking monomers which contain a cleavable link;
- and
- polymerizing the components to form a plurality of solid supports that each provide a series of random or block co-polymer backbones that are cross linked by cross links having a set of cleavable links within the crosslinks;
- and attaching a plurality of cleavable chemistry site links to the polymer chains.
A method for constructing a solid support, the method comprising:
- placing a set of components in a mixture, wherein the components comprise a base set of monomers which include monomer containing cleavable links, and monomers used for post-polymerization chemical modification and crosslinking;
- polymerizing the components to form linear polymers that each comprise a series of copolymer backbones with cleavable links within crosslinks;
- initiating crosslinking to form a plurality of solid supports that contain the cleavable links in the backbone and non-cleavable links between the backbones;
- and attaching a plurality of cleavable chemistry site links to the polymers.
A drug delivery capsule, comprising a capsule having:
- a series of polymer chains cross linked by cross links;
- a first set of cleavable links within the cross links;
- a second set of cleavable links;
- and
- a drug attached to the second set of cleavable links.
Dependencies are inferred from the claim text.