Loading patent…
AssigneeDermatrends, Inc.
InventorsTsung-Min Hsu, Eric C. Jacobson, Rose C. LoBello, Eric C. Luo
Estimating the term…
A permeation enhancer composition is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The composition is comprised of a hydroxide-releasing agent and a lipophilic co-enhancer such as a fatty alcohol, a fatty ether, or a fatty acid ester, including fatty acid esters of polyols such as propylene glycol and glycerol. Also provided are pharmaceutical formulations containing a therapeutically effective amount of an active agent in addition to the aforementioned enhancer composition, methods for administering active agents topically or transdermally with enhanced permeation, and drug delivery systems for application to an individual's skin or mucosal tissue, wherein the systems are formulated so as to contain an active agent to be administered and an effective permeation enhancing amount of an enhancer composition of the invention.
A permeation enhancer topical or transdermal composition having a pH in the range of approximately 8.0 to approximately 13.0 and comprised of a hydroxide-releasing agent and a lipophilic co-enhancer having a molecular weight in the range of about 150 to 1000, an aqueous solubility of less than about 1 wt. %, and the structure (CH3—L—X)nR, wherein:
A permeation enhancer topical or transdermal composition having a pH in the range of approximately 8.0 to approximately 13.0 and comprised of an alkali metal hydroxide and a lower alkyl ester of a C10-C18 fatty acid, wherein the amount of alkali metal hydroxide in the composition is the total of (a) the amount required to neutralize any acidic species in the composition plus (b) an amount equal to approximately 0.5 wt. % to 25 wt. % of the composition.
A permeation enhancer tropical or transdermal composition having a pH in the range of approximately 8.0 to approximately 13.0 and comprised of an alkali metal hydroxide and an esterified polyol selected from the group consisting of (a) propylene glycol mono- or di-substituted with a C10-C18 fatty acid, (b) glycerol mono- or di-substituted with a C10-C18 fatty acid, or both (a) and (b), wherein the amount of alkali metal hydroxide in the composition is the total of (a) the amount required to neutralize any acidic species in the composition plus (b) an amount equal to approximately 0.5 wt. % to 25 wt. % of the composition.
Dependencies are inferred from the claim text.