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AssigneeKowa Company, Ltd.
InventorsToshio Inagi, Hiroyuki Shirai, Norikazu Yamaguchi, Takeshi Nishino
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The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum and one or more of ingredients selected from water insoluble polymers, polyglycerin fatty acid esters, lipids and waxes, with a polymer having adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions. This composition adheres only to the mucosa of the stomach and/or duodenum and releases the medicament over long hours so that sufficient effects are available by a small amount of the medicament.
An adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach or duodenum and a water insoluble cellulose polymer (I), with a second composition consisting essentially of a polymer (II) having an adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions, wherein said polymer (II) is obtained from an acrylic acid, a methacrylic acid or a mixture thereof, and a carboxylic ester.
Dependencies are inferred from the claim text.