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AssigneeThe Trustees of Columbia University in the City of New York
InventorsShanta M. Modak, Suhas Tambe, Lester A. Sampath
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The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.
An anti-infective medical article prepared by exposing a polymer-containing medical article, for an effective period of time, to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline and between 1 and 8 percent (weight/volume) of a chlorhexidine compound selected from the group consisting of chlorhexidine free base and chlorhexidine diacetate.
An anti-infective medical article prepared by exposing a polymer-containing medical article, for an effective period of time, to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline, between 1 and 8 percent (weight/volume) of triclosan, and bismuth nitrate at a concentration of between 0.5 and 2.0 percent (weight/volume).
An anti-infective medical article prepared by exposing a polymer-containing medical article, for an effective period of time, to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline, between 0.25 and 1.0 percent (weight/volume) of benzalkonium chloride, and between 0.5 and 2.0 percent (weight/volume) of bismuth nitrate.
An intravascular catheter comprising between 100 and 450 micrograms of minocycline per centimeter and between 130 and 520 micrograms of a chlorhexidine compound selected from the group consisting of chlorhexidine free base and chlorhexidine diacetate.
An intravascular catheter comprising between 100 and 450 micrograms of minocycline per centimeter, between 130 and 750 micrograms of triclosan per centimeter, and between 50 and 300 micrograms of bismuth nitrate per centimeter.
An antiinfective medical article prepared by exposing a polymer-containing medical article for an effective period of time to a treatment solution comprising between 1 and 8 percent (weight/volume) of minocycline and between 0.5 and 2.0 percent (weight/volume) of bismuth nitrate.
Dependencies are inferred from the claim text.