Back to results
US 6,582,718 B2Granted
Cyclosporin compositions
AssigneeNovartis AG
InventorsYoichi Kawashima, Mitsuaki Kuwano
Life of this patent
Estimating the term…
Abstract
An ophthalmic composition particularly in the form of eye-drops suitable for the treatment of diseases of the eye and surrounding areas. The composition contains a cyclosporin and a surfactant selected from polyoxyethylene fatty acid esters, polyoxyethylene alkylphenyl ethers and polyoxyethylene alkyl ethers, or mixtures thereof.
Claims18
An oil-free composition comprising:
- (A) a cyclosporin
- (B) a surfactant selected from the group consisting of polyoxyethylene fatty acid esters wherein the polymerization number of the polyoxyethylene moiety is from about 20 to about 60, polyoxyethylene alkylphenyl ethers, and polyoxyethylene alkyl ethers, or mixtures thereof in an amount of from about 0.1% to about 3.0% (w/v);
- and
- (C) purified water
- the cyclosporin in solution at a concentration of from about 0.1 to about 0.075% (w/v), with the proviso that the composition further comprises about 0.05 to about 5.0% (w/v) of an excipient which is a thickening agent selected from the groups consisting of cellulose, alkyl celluloses, hydroxyalkylcelluloses, carboxyvinyl polymers, polyvinyl polymers and polyvinyl pyrrolidones if the surfactant is a polyoxyethylene fatty acid ester or a mixture comprising such ester.
2 more elements
A process for solubilizing a cyclosporin in an aqueous medium comprising:
- 1) mixing a cyclosporin with a surfactant selected from the group consisting of polyoxyethylene fatty acid esters, polyoxyethylene alkylphenyl ethers, and polyoxyethylene alkyl ethers, and mixtures thereof;
- and
- 2) dissolving the product of step 1) in water,
- with the proviso that the process comprises adding about 0.05 to about 5.0% (w/v) of an excipient which is a thickening agent selected from the groups consisting of cellulose, alkyl celluloses, hydroxyalkylcelluloses, carboxyvinyl polymers, polyvinyl polymers and polyvinyl pyrrolidones if the surfactant is a polyoxyethylene fatty acid ester or a mixture comprising such ester.
1 more element
Dependencies are inferred from the claim text.