Vaccine compositions comprising Streptococcus pneumoniae polypeptides having selected structural MOTIFS
AssigneeMedImmune, LLC
InventorsLeslie S. Johnson, John E. Adamou
Life of this patent
Estimating the term…
Abstract
A vaccine composition is disclosed that comprises polypeptides and fragments of polypeptides containing histidine triad residues or coiled-coil regions, some of which polypeptides or fragments lie between 80 and 680 residues in length. Also disclosed are processes for preventing infection caused by S. pneumoniae comprising administering of vaccine compositions.
Claims11
A composition comprising a polypeptide at least 95% identical to amino acids 20-838 of SEQ ID NO:
- 4 in a pharmaceutically accptable carrier in an amount effective to elicit production of an antibody that ends to S. pneumoniae when said composition is administered to a mammal.
A composition comprising an active fragment of a polypeptide at least 95% identical to amino acids 20-838 of SEQ ID NO:
- 4 wherein said active fragment comprises at least two coiled coil regions and is in a pharmaceutically acceptable carrier in an amount effective to elicit production of an antibody that binds to said polypeptide when said composition is administered to a mammal.
A composition comprising a polypeptide comprising the sequence of amino acid residues 139-791 of SEQ ID NO:
- 4.
A vaccine comprising a polypeptide containing the sequence of amino acids 20-838 of SEQ ID NO:
- 4 in a pharmaceutically acceptable carrier in an amount effective to protect against pneumococcal infection when administered to a mammal.
An isolated polypeptide at least 95% identical to amino acids 20-838 of SEQ ID NO:
- 4, wherein said polypeptide binds to an antibody that binds S. pneumoniae.
Dependencies are inferred from the claim text.