Immunogenic peptides from the HPV E7 protein
AssigneeZycos Inc.
InventorsRobert G. Urban, Roman M. Chicz, Edward J. Collins, Mary Lynne Hedley
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Abstract
The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.
Claims28
A polypeptide comprising a first peptide and a second peptide linked by a peptide bond, the first peptide being a peptide which controls intracellular trafficking of a peptide to which it is attached, and the second peptide consisting of a sequence 8-18 amino acids in length comprising the sequence Thr Leu Gly Ile Val Cys Pro Ile (SEQ ID NO:20).
A substantially pure peptide less than 19 amino acids in length, wherein the peptide comprises the amino acid sequence Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys (SEQ ID NO:3).
A substantially pure peptide less than 19 amino acids in length, wherein the peptide comprises the amino acid sequence Xaa Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys (SEQ ID NO:19), Xaa being Met, Ala, Ser, Arg, Lys, Gly, Gln, Asp, or Glu.
A substantially pure peptide consisting of an amino acid sequence selected from the group consisting of:
- Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val Leu Met Ser Ala Gln Glu Ser Trp Ala Ala Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys (SEQ ID NO:6);
- Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys (SEQ ID NO:16);
- and
- Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gin Lys (SEQ ID NO:32),
- wherein the peptide optionally includes an amino terminal methionine.
Dependencies are inferred from the claim text.