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US 6,582,698 B1Granted
Treatment method
AssigneesGenentech, Inc., Xoma Technology Ltd.
InventorsRussell L. Dedrick, Marvin R. Garovoy, Susan M. Kramer, Karen M. Starko
Life of this patent
Estimating the term…
Abstract
A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
Claims8
A method for treating psoriasis, comprising
- administering to a mammal in need thereof a first conditioning dose of an antibody or a receptor binding fragment thereof which binds CD11a;
- and
- administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
Dependencies are inferred from the claim text.