Enhancement of the cellular immune response
AssigneeBiomira, Inc.
InventorsB. Michael Longenecker, Carina Henningsson
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Abstract
DTH-Effector cells are primed with carbohydrate antigens and used to enhance the cellular immune response. Tumors have been inhibited by DTH-Effector cells primed with epiglycanin and with synthetic T and Tn antigens. Either the DTH-Effector cells, or these tumor-associated carbohydrate antigens directly, may be used for tumor prophylaxis and therapy.
Claims14
A method of enhancing cellular immunity in a mammal which consists essentially of administering to the mammal an immunologically effective amount of a carbohydrate antigenic determinant bearing antigen, said antigen being a synthetic conjugate comprising a synthetic carbohydrate antigenic determinant and a non-tumor associated immunogenic carrier not naturally associated with said determinant, said mammal subsequently exhibiting a cellular immune response elicited by said antigen and specific to the carbohydrate antigenic determinant of said antigen, wherein an adjuvant is also administered.
Dependencies are inferred from the claim text.