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US 6,582,693 B2Granted
Recombinant MVA virus expressing the E2 gene of Bovine papillomavirus and its use in the therapy of tumors generated by papillomaviruses
AssigneeLemery, S.A. de C.V.
InventorRicardo R. Ledezma
Life of this patent
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Abstract
A recombinant vaccinia virus derived from the vaccinia virus Ankara (MVA) encoding and capable of expressing the E2 gene of Bovine papillomavirus. Also, the use of the virus in the treatment of lesions caused by papillomavirus.
Claims14
A recombinant Modified Vaccinia Ankara (MVA) virus, comprising:
- a DNA sequence encoding a bovine papillomavirus E2 (BPV E2) protein.
A method of producing a recombinant virus, comprising:
- carrying out homologous recombination between virus MVA and a transfer vector comprising a papillomavirus E2 gene under the control of the vaccinia p7.5 promoter;
- and
- isolating the recombinant virus.
A method for the treatment of lesions generated by papillomavirus infections, comprising:
- administering a therapeutically effective amount of a recombinant Modified Vaccinia Ankara (MVA) virus comprising a sequence encoding a papillomavirus E2 protein to a living animal in need thereof.
Dependencies are inferred from the claim text.