Propellant compositions of a particulate medicament that are free of solvents
AssigneeAventis Pharmaceuticals Inc.
InventorsGerald Steele, Asit Somani, Joseph Geok Paan Lim
Life of this patent
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Abstract
Pressurized aerosol composition comprising a liquefied hydrofluorocarbon propellant of formula CxHyFz where x is an integer from 1 to 3, y+z=2x+2, and y and z are both at least 1; from 0.01 to 15% w/w of a particulate medicament dispersed in the liquefied hydrofluorocarbon propellant; and from 0.01 to 10% w/w of a fluorinated surfactant which is soluble in the liquefied hydrofluorocarbon propellant. The pressurized aerosol composition comprises no solvent, other than the liquefied hydrofluorocarbon propellant.
Claims15
A pressurized aerosol composition comprising:
- a liquefied hydrofluorocarbon propellant of general formula CxHyFz where x is an integer from 1 to 3, y+z=2x+2, and y and z are both at least 1;
- from 0.01 to 15% w/w of a particulate medicament dispersed in said liquefied hydrofluorocarbon propellant;
- and
- from 0.01 to 10% w/w of a fluorinated surfactant which is soluble in said liquefied hydrofluorocarbon propellant;
- wherein the pressurized aerosol composition comprises no solvent, other than the liquefied hydrofluorocarbon propellant.
A composition according 2, wherein the non-ionic fluorinated surfactant contains one or more ether or carboxylic ester linkages.
A pressurized aerosol composition comprising:
- a liquefied hydrofluorocarbon propellant of general formula CxHyFz where x is an integer from 1 to 3, y+z=2x+2, and y and z are both at least 1;
- from 0.05 to 15% w/w of a particulate medicament dispersed in said liquefied hydrofluorocarbon propellant;
- and
- from 0.1 to 10% w/w of a fluorinated surfactant which is soluble in said liquefied hydrofluorocarbon propellant;
- wherein the pressurized aerosol composition comprises no solvent.
Dependencies are inferred from the claim text.