Method and system for use in treating a patient with a biological substance to optimize therapy and prevent an adverse response

A method for calculating a revised dose of a biological substance for a patient using said biological substance comprising the steps of:

• accepting as a first input the patient's current biological substance dose;
• accepting as a second input the maximum dose of the biological substance;
• accepting as a third input one or more numerical markers indicating a response of the patient;
• and
• calculating said revised dose, wherein said revised dose is a function of said current dose minus the ratio of the change in numerical markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for determining a dose of a biological substance for a patient, comprising the steps of:

• administering an initial dose of said biological substance to the patient;
• evaluating the patient to monitor and characterize one or more numerical surrogate markers;
• determining, based on said numerical surrogate markers, if a dose change for said biological substance is necessary;
• and
• calculating a revised dose as a function of said current dose minus the ratio of a percent response of the patient and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for determining a dose of a biological substance for a patient, comprising the steps of:

• administering an initial dose of said biological substance to the patient;
• examining the patient to monitor and characterize one or more numerical surrogate markers;
• determining if a dose change is necessary;
• and
• calculating a revised dose as a function of said current dose minus the ratio of the change in numerical markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for calculating a revised dose of a biological substance for a patient currently using said biological substance, comprising the steps of:

• accepting as input the patient's current biological substance dose;
• accepting as input the maximum dose of said biological substance;
• accepting as input the percent response of the patient based on surrogate markers;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose, said maximum dose, and said percent response of the patient based on said surrogate markers.

A method for calculating a revised dose of a biological substance for a patient currently using said biological substance, comprising the steps of:

• accepting as input a patient's current biological substance dose;
• accepting as input a maximum dose of said biological substance;
• accepting as input the previous, current and desired values of one or more numerical surrogate markers indicating the response of the patient;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose, said maximum dose, and said previous, current and desired values of said numerical surrogate markers.

A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:

• first means for accepting as input a patient's current biological substance dose;
• second means for accepting as input a maximum dose of said biological substance;
• third means for accepting as input a percent response of a patient based on predetermined surrogate markers;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose minus the ratio of a percent response of the patient and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:

• first means for accepting as input a patient's current biological substance dose;
• second means for accepting as input the maximum dose of said biological substance;
• third means for accepting as input one or more numerical surrogate markers indicating the response of said patient to said biological substance;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose minus the ratio of the change in said numerical surrogate markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

An apparatus for calculating a revised dose of a biological substance for a patient, comprising:

• first means for accepting as input one or more surrogate markers which indicate a patient's response to a dose of said biological substance;
• second means for accepting as input the patient's current biological substance dose;
• third means for accepting as input the maximum dose of said biological substance;
• and
• fourth means for calculating a revised dose of said biological substance as a function of said surrogate markers, said current biological substance dose, and said maximum biological substance dose.

A method for calculating a revised dose of a vaccine for a patient using said vaccine, comprising the steps of:

• accepting as a first input the patient's current vaccine dose;
• accepting as a second input a maximum dose of said vaccine;
• accepting as a third input a percent response of the patient based on one or more surrogate markers for said patient;
• and
• determining a revised dose, wherein said revised dose is a function of said current dose minus a ratio of the percent response of the patient and a ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for calculating a revised dose of a vaccine for a patient using said vaccine comprising the steps of:

• accepting as a first input the patient's current vaccine dose;
• accepting as a second input the maximum dose of the vaccine;
• accepting as a third input one or more numerical markers indicating a response of the patient;
• and
• calculating said revised dose, wherein said revised dose is a function of said current dose minus the ratio of the change in numerical markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for determining a dose of a vaccine for a patient, comprising the steps of:

• administering an initial dose of said vaccine to the patient;
• evaluating the patient to monitor and characterize one or more numerical surrogate markers;
• determining, based on said numerical surrogate markers, if a dose change for said vaccine is necessary;
• and
• calculating a revised dose as a function of said current dose minus the ratio of a percent response of the patient and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for determining a dose of a vaccine for a patient, comprising the steps of:

• administering an initial dose of said vaccine to the patient;
• examining the patient to monitor and characterize one or more numerical surrogate markers;
• determining if a dose change is necessary;
• and
• calculating a revised dose as a function of said current dose minus the ratio of the change in said numerical surrogate markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for calculating a revised dose of a vaccine for a patient currently using said vaccine, comprising the steps of:

• accepting as input the patient's current vaccine dose;
• accepting as input the maximum dose of said vaccine;
• accepting as input the percent response of the patient based on surrogate markers;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose, said maximum dose, and said percent response of the patient based on said surrogate markers.

A method for calculating a revised dose of a vaccine for a patient currently using said vaccine, comprising the steps of:

• accepting as input a patient's current vaccine dose;
• accepting as input a maximum dose of said vaccine;
• accepting as input the previous, current and desired values of one or more numerical surrogate markers indicating the response of the patient;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose, said maximum dose, and said previous, current and desired values of said numerical surrogate markers.

A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:

• first means for accepting as input a patient's current vaccine dose;
• second means for accepting as input a maximum dose of said vaccine;
• third means for accepting as input a percent response of a patient based on predetermined surrogate markers;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose minus the ratio of a percent response of the patient and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:

• first means for accepting as input a patient's current vaccine dose;
• second means for accepting as input the maximum dose of said vaccine;
• third means for accepting as input one or more numerical surrogate markers indicating the response of said patient to said vaccine;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose minus the ratio of the change in said numerical surrogate markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

An apparatus for calculating a revised dose of a vaccine for a patient, comprising:

• first means for accepting as input one or more surrogate markers which indicate a patient's response to a dose of said vaccine;
• second means for accepting as input the patient's current vaccine dose;
• third means for accepting as input the maximum dose of said vaccine;
• and
• fourth means for calculating a revised dose of said vaccine as a function of said surrogate markers, said current vaccine dose, and said maximum vaccine dose.