Method, apparatus and system for use in treating patient with a drug having an antineoplastic effect to optimize therapy and prevent an adverse drug response

A method for calculating a revised dose of a antineoplastic drug for a patient using said antineoplastic drug, comprising the steps of:

• accepting as a first input the patient's current antineoplastic drug dose;
• accepting as a second input the maximum dose of the antineoplastic drug;
• accepting as a third input one or more numerical markers indicating a response of the patient to said antineoplastic drug;
• and
• calculating said revised dose, wherein said revised dose is a function of said current dose minus the ratio of the change in numerical markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for determining a dose of a antineoplastic drug for a patient, comprising the steps of:

• administering an initial dose of said antineoplastic drug to the patient;
• evaluating the patient to monitor and characterize one or more numerical surrogate markers used for monitoring said antineoplastic drug;
• determining, based on said numerical surrogate markers, if a dose change for said antineoplastic drug is necessary;
• and
• calculating a revised dose as a function of said current dose minus the ratio of a percent response of the patient and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for determining a dose of an antineoplastic drug for a patient, comprising the steps of:

• administering an initial dose of said antineoplastic drug to the patient;
• examining the patient to monitor and characterize one or more numerical surrogate markers used for monitoring said antineoplastic drug;
• determining if a dose change is necessary;
• and
• calculating a revised dose as a function of said current dose minus the ratio of the change in numerical markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A method for calculating a revised dose of an antineoplastic drug for a patient, comprising the steps of:

• accepting as input the patient's current antineoplastic drug dose;
• accepting as input the maximum dose of the antineoplastic drug;
• accepting as input the percent response of the patient based on surrogate markers for monitoring said antineoplastic drug;
• and
• calculating a revised dose, wherein said revised dose is a function of said current dose, said maximum dose, and said percent response of the patient based on said surrogate markers.

A method for calculating a revised dose of an antineoplastic drug for a patient, comprising the steps of:

• accepting as input a patient's current antineoplastic drug dose;
• accepting as input a maximum dose of the antineoplastic drug;
• accepting as input the previous, current and desired values of one or more numerical markers indicating the response of the patient to said antineoplastic drug;
• calculating a revised dose, wherein said revised dose is a function of said current dose, said maximum dose, and said previous, current and desired values of said numerical markers.

A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:

• first means for accepting as input a patient's current antineoplastic drug dose;
• second means for accepting as input a maximum dose of the antineoplastic drug;
• third means for accepting as input a percent response of a patient based on
• surrogate markers for monitoring said antineoplastic drug;
• and
• fourth means for calculating a revised dose, wherein said revised dose is a function of said current dose minus the ratio of a percent response of the patient and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:

• first means for accepting as input the patient's current antineoplastic drug dose;
• second means for accepting as input the maximum dose of the antineoplastic drug;
• third means for accepting as input one or more numerical markers indicating the response of the patient to said antineoplastic drug;
• and
• fourth means for calculating a revised dose, wherein said revised dose is a function of said current dose minus the ratio of the change in numerical markers and the ratio of said current dose to said maximum dose plus the percent of individual patient response multiplied by a response factor.

An apparatus for calculating a revised dose of an antineoplastic drug for a patient, comprising:

• first means for accepting as input one or more markers which indicate a patient's response to a dose of said antineoplastic drug;
• second means for accepting as input the patient's current antineoplastic drug dose;
• third means for accepting as input the maximum dose of the antineoplastic drug;
• and
• fourth means for calculating a revised dose of the antineoplastic drug as a function of said markers, said current antineoplastic drug dose, and said maximum antineoplastic drug dose.