Matrix metalloprotease inhibitors

A compound of the formula:

• wherein:
• R1 is mercapto, carboxy, or a group of the formula:
• where R6 is optionally substituted aryl or heteroaryl;
• R2 is alkyl, optionally substituted phenyl, or a group of the formula:
• wherein:
• A is CH2, O, NH, S, CH2—CH2, or NH—CH2;
• R10 is H, alkyl, alkoxy, alkylamino or acylamide;
• and
• R11 is H or halo;
• R7 is 4-pyridyl and p is 0;
• R3 is alkyl, cycloalkyl, aralkyl, or heteroaralkyl, where the aralkyl and heteroaryl groups may be optionally substituted and where the alkyl is optionally substituted by cycloalkyl, hydroxy, mercapto, alkylthio, aralkoxy, amino, mono- and diallkylamino, guanidino, N,N-dialkylguanidino, carbamoyl, aryl or heteroaryl;
• X is a group of the formula —(CH2)m—Y—(CH2)n—, where:
• Y is O, S, or a single bond,
• m is an integer from 0 to 4,
• n is an integer from 0 to 4, and
• m+n is an integer from 0 to 4;
• p is an integer from 0 to 4, provided that R2—X is biphenylalkyl when p is not 0;
• or a pharmaceutically acceptable salt thereof.