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US 6,579,696 B1Granted
Polymyxin B conjugates
AssigneePromega Corporation
InventorsMohammed Saleh Shekhani, Robert W. Schatz, Charles Pugh, Nicholas Panasik, Jr., Douglas Stafford
Life of this patent
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Abstract
Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other individuals at risk can be treated prophylactically. Methods for treating acute infections with advantages over current therapeutic approaches are provided.
Claims13
A method, comprising:
- a) providing:
- i) polymyxin B comprising a diaminobutyric acid residue, said residue having a gamma amino group, ii) an amino acid selected from the group consisting of cysteine, alanine and lysine;
- and
- b) covalently linking said amino acid to said gamma amino group to create a compound consisting essentially of polymyxin B with a side chain linked to an amino acid residue, wherein said compound displays approximately the same antibiotic activity as polymyxin B when compared in a MIC assay.
1 more element
A compound consisting of:
- i) a polymyxin B molecule having a diaminobutyric acid residue with a gamma amino group, ii) a hapten, and iii) a spacer selected from the group consisting of a cysteine residue, an alanine residue, and a lysine residue, wherein said spacer is linked to said hapten and to said gamma amino group of said diaminobutyric acid residue.
A polymyxin B conjugate comprising:
- i) a polymyxin B molecule having a diaminobutyric acid residue with a gamma amino group, ii) a hapten, and iii) a spacer selected from the group consisting of a cysteine residue, an alanine residue, and a lysine residue;
- wherein said spacer is linked to said hapten and to said gamma amino group of said diaminobutyric acid residue;
- and wherein said polymyxin B conjugate is configured to opsonize bacteria by binding to a bacteria cell and non-covalently linking to anti-hapten antibodies.
Dependencies are inferred from the claim text.