Cyanoacrylate solutions containing preservatives
AssigneeClosure Medical Corporation
InventorsWilliam S. C. Nicholson, Upvan Narang, Ubonwan A. Stewart, Daniel L. Hedgpeth, Ibraheem T. Badejo, Lawrence H. Mainwaring
Life of this patent
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Abstract
An adhesive composition that contains a preservative is particularly useful as a medical adhesive and can include alkyl cyanoacrylate monomers. The preservative is preferably soluble in the monomer. The composition may optionally be sterilized by placing a mixture of a polymerizable adhesive monomer and a preservative in a container, sealing the container, and sterilizing the mixture and the container.
Claims60
A monomeric adhesive composition comprising a polymerizable alkyl cyanoacrylate monomer and an antimicrobial preservative agent, wherein said agent is soluble in said monomer at room temperature and substantially all of said monomer remains stable for at least five minutes after forming the composition,
- wherein said agent is selected from the group consisting of parabens, cresols, pyrocatechol, resorcinol, 4-n-hexyl resorcinol, 3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione, benzyl alcohol, chlorobutanol, dehydroacetic acid, methylparaben sodium, o-phenylphenol, phenylethyl alcohol, phenylmercuric acetate, phenylmercuric borate, phenylmercuric nitrate, potassium benzoate, potassium sorbate, propylparaben sodium, sodium benzoate, sodium dehydroacetate, sodium propionate, sorbic acid, thimerosal, 4-chloro-1-butanol, methyl-4-hydroxy benzoate, elemental metals and metal compounds, and a non-polymer stabilized material that is soluble or insoluble in the monomer.
A method of making a sterile, antimicrobial adhesive composition comprising:
- placing a mixture of a polymerizable alkyl cyanoacrylate monomer and an antimicrobial preservative agent in a container,
- sealing said container, and
- sterilizing the mixture in the container,
- wherein said mixture remains stable for at least five minutes after forming the mixture, and
- wherein said agent is selected from the group consisting of parabens, cresols, pyrocatechol, resorcinol, 4-n-hexyl resorcinol, 3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione, benzyl alcohol, chlorobutanol, dehydroacetic acid, methylparaben sodium, o-phenylphenol, phenylethyl alcohol, phenylmercuric acetate, phenylmercuric borate, phenylmercuric nitrate, potassium benzoate, potassium sorbate, propylparaben sodium, sodium benzoate, sodium dehydroacetate, sodium propionate, sorbic acid, thimerosal, 4-chloro-1-butanol, methyl-4-hydroxy benzoate, elemental metals and metal compounds, and a non-polymer stabilized material that is soluble or insoluble in the monomer.
A method of making a monomeric adhesive composition, comprising dissolving an antimicrobial preservative agent in a polymerizable alkyl cyanoacrylate monomer, wherein said agent is soluble in the monomer at room temperature and said composition remains stable for at least five minutes after forming the composition,
- wherein said agent is selected from the group consisting of parabens, cresols, pyrocatechol, resorcinol, 4-n-hexyl resorcinol, 3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione, benzyl alcohol, chlorobutanol, dehydroacetic acid, methylparaben sodium, o-phenylphenol, phenylethyl alcohol, phenylmercuric acetate, phenylmercuric borate, phenylmercuric nitrate, potassium benzoate, potassium sorbate, propylparaben sodium, sodium benzoate, sodium dehydroacetate, sodium propionate, sorbic acid, thimerosal, 4-chloro-1-butanol, methyl-4-hydroxy benzoate, elemental metals and metal compounds, and a non-polymer stabilized material that is soluble or insoluble in the monomer.
Dependencies are inferred from the claim text.